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Encephalopathy (Alaskan Husky Type) Overview

Encephalopathy (Alaskan Husky Type)
US$ 94.00 RRP
US$ 85.00 REGISTERED USER PRICE
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Category: Neurologic (Associated with the Brain, Spinal and Nerves)

Gene: SLC19A3 on Chr 25

Variant Detected: [c.624 insTTGC]; [c.625 C>A]

Severity: Scale 4 has a high degree of severity. It generally causes a decreased quality of life and may also decrease the life expectancy.

Mode of Inheritance: Autosomal Recessive

Test Overview: Alaskan Husky Encephalopathy (AHE) is a fatal brain disease in young Alaskan Husky (AH) dogs, often affecting multiple dogs from the same litter. Dogs with AHE may have acute onset of clinical signs, or chronic progressive waxing and waning clinical history. Typically, they have multifocal central nervous system deficits including seizures, altered mentation, dysphagia, absent menace response, central blindness, hypermetria, proprioceptive positioning deficits, facial hypoalgesia, ataxia and tetraparesis.

Research Citation(s): PLoS One. 2013; 8(3): e57195.
Wakshlag JJ, de Lahunta A, Robinson T, Cooper BJ, Brenner O, et al. (1999) Subacute necrotising encephalopathy in an Alaskan husky. J Small Anim Pract 40: 585–589 [PubMed]
Brenner O, Wakshlag JJ, Summers BA, de Lahunta A (2000) Alaskan Husky encephalopathy – a canine neurodegenerative disorder resembling subacute necrotizing encephalomyelopathy (Leigh syndrome). Acta Neuropathol (Berl) 100: 50–62 [PubMed]


Associated Breed(s): Alaskan Husky,  Mixed Breed,