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Exercise Induced Collapse Overview

Exercise Induced Collapse
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Category: Neurologic (Associated with the Brain, Spinal and Nerves)

Gene: DNM1

Variant Detected: Base Substitution c.767 G>T

Severity: Scale 3 has a moderate degree of severity, as it is not a fatal disease, though it can decrease the quality of life.

Mode of Inheritance: Autosomal Recessive with Incomplete Penetrance

Test Overview: The syndrome of exercise-induced collapse (EIC) in this breed is manifested by muscle weakness, incoordination and life-threatening collapse after intense exercise. Five to fifteen minutes of strenuous exercise causes dogs suffering from this condition to develop a ‘wobbly’ gait, which soon progresses to nonpainful, flaccid paraparesis and a loss of control of the rear limbs. The episode may progress to all four limbs. Collapse episodes usually last for 5–10 min, recovery is typically rapid, and after 30 min there is often complete recovery, but severe episodes are occasionally fatal.

Research Citation(s): Furrow E, Minor KM, Taylor SM, Mickelson JR, Patterson EE. Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers. J Am Vet Med Assoc. 2013 Mar 15;242(6):786-91. [PubMed: 23445289] Minor KM, Patterson EE, Keating MK, Gross SD, Ekenstedt KJ, Taylor SM, Mickelson JR. Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds. Vet J. 2011 Aug; 189(2):214-9. [PubMed: 21782486] Patterson EE, Minor KM, Tchernatynskaia AV, Taylor SM, Shelton GD, Ekenstedt KJ, Mickelson JR. A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Nat Genet. 2008 Oct; 40(10):1235-9. [PubMed: 18806795] Taylor SM, Shmon CL, Adams VJ, Mickelson JR, Patterson EN, Shelton GD. Evaluations of labrador retrievers with exercise-induced collapse, including response to a standardized strenuous exercise protocol. J Am Anim Hosp Assoc. 2009 Jan-Feb; 45(1):3-13. [PubMed: 19122058] Taylor SM, Shmon CL, Shelton GD, Patterson EN, Minor K, Mickelson JR. Exercise-induced collapse of Labrador retrievers: survey results and preliminary investigation of heritability. J Am Anim Hosp Assoc. 2008 Nov-Dec; 44(6):295-301. [PubMed: 18981194]

Associated Breed(s): American Cocker Spaniel,  Bouvier Des Flandres,  Boykin Spaniel,  Chesapeake Bay Retriever ,  Clumber Spaniel ,  Curly Coated Retriever,  Labradoodle ,  Labrador Retriever,  Old English Sheepdog ,  Pembroke Welsh Corgi,  Mixed Breed,  German Wirehaired Pointer,