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Factor VII Deficiency Overview

Factor VII Deficiency
US$ 75.00 RRP
US$ 67.50 REGISTERED USER PRICE
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Category: Haemolymphatic (Associated with the Circulatory System)

Gene: F7 on Chromosome 22

Variant Detected: Base Substitution G>A

Severity: Scale 3 has a moderate degree of severity, as it is not a fatal disease, though it can decrease the quality of life.

Mode of Inheritance: Autosomal Recessive

Test Overview: Factor VII deficiency is a blood clotting disorder that causes excessive or prolonged bleeding after an injury or surgery. With factor VII deficiency, your body either doesn’t produce enough factor VII, or something is interfering with your factor VII, often another medical condition. Factor VII is a protein produced in the liver that plays an important role in helping your blood to clot. It’s one of about 20 clotting factors involved in the complex process of blood clotting. To understand factor VII deficiency, it helps to understand the role factor VII plays in normal blood clotting.

Research Citation(s): Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U, High KA. A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. J Thromb Haemost. 2006 Dec; 4(12):2616-22. [PubMed: 16961583] Carlstrom LP, Jens JK, Dobyns ME, Passage M, Dickson PI, Ellinwood NM. Inadvertent propagation of factor VII deficiency in a canine mucopolysaccharidosis type I research breeding colony. Comp Med. 2009 Aug;59(4):378-82. [PubMed: 19712579] Withnall E, Giger U. Effects of recombinant human activated factor VII and canine fresh frozen plasma in Beagles with hereditary coagulation factor VII deficiency. J Vet Intern Med. 2006; 20: 766 (abstract) [not in PubMed]

Associated Breed(s): Beagle,  Giant Schnauzer,  Miniature Schnauzer,  Scottish Deerhound,  Papillon,