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The insulin-like growth factor-1 gene (IGF1), and additional studies of Miniature Poodles and Dachshunds implicated the IGF1 receptor (IGF1R) as well, both of which are important regulators of body size.
The IGF1 pathway has also been established as important in normal stature in humans, and mutations in IGF1 have been shown to reduce body size in mice.
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Associated Breed(s):
Click here to view Associated Breeds
Category:
Genetic Traits
Severity:
It is a trait and so is tested based on preference, not usually for health concerns.
Gene:
IGSF1
Variant Detected:
chrX.g.102369488-102369489insAAC, p.Asp376_Glu377insAsn, Chromosome X
Mode of Inheritance:
Recomended Screening:
Research Citation(s):