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Amelogenesis Imperfecta Overview

Amelogenesis Imperfecta
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Category: Metabolic (Associated with the Body's Enzymes and Cell Metabolism)

Gene: ENAM

Variant Detected: c.1992_1996delTTTCC

Severity: Scale 2 has a low degree of severity. It has mild effects and generally does not pose any significant health concerns, or is easily managed.

Mode of Inheritance: Autosomal Recessive

Test Overview: Amelogenesis Imperfecta Italian Greyhound type is a congenital teeth disorder also known as enamel hypoplasia in Italian Greyhounds.Amelogenesis Imperfecta in Italian Greyhound is affecting deciduous and permanent teeth and is manifested by enamel thinning and roughening or brownish mottling in areas of enamel thinning. It starts to develop in early adulthood of the dog. Teeth that are affected appear to be small and pointed with increased gaps. While amelogenesis imperfecta causes cavity in humans, this condition does not occur in dogs, due to maintained basic tooth structure throughout life.

Research Citation(s): Anim Genet. 2013 May 3. doi: 10.1111

Associated Breed(s): Italian Greyhound,  Mixed Breed,