Hereditary Footpad Hyperkeratosis (Irish Terrier Type) Overview
Hereditary Footpad Hyperkeratosis (Irish Terrier Type)
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Category: Dermatologic - Associated with the skin
Gene: Family with sequence similarity 83 member G (FAM83G) on Chromosome 5
Variant Detected: Base Substitution c.155G>C p.Arg52Pro
Severity: Scale 2 has a low degree of severity. It has mild effects and generally does not pose any significant health concerns, or is easily managed.
Mode of Inheritance: Autosomal Recessive
Test Overview: Also called hereditary footpad hyperkeratosis (HFH) or digital hyperkeratosis. This is a condition where there is abnormal development of the epidermis (the outer layer of the skin) of the footpad. The footpads of an affected dog develop initially with a very smooth surface. They then harden and continue to grow, with splits and lateral protrusions forming. The fissures, or cracks that develop can cause pain and lameness, especially if they become infected. In severe cases dogs may have trouble doing any walking at all. Footpad hyperkeratosis is first seen in dogs at around 4-6 months of age, with pups' footpads appearing normal at birth. In the Irish setter, in addition to footpad lesions the nails may grow slightly faster than normal, and have a rounder than usual appearance. Otherwise the rest of the skin is unaffected, however all footpads are affected. There is no cure for footpad hyperkeratosis. Treatment involves footbath soaks, and filing away the excess keratin. A prescribed cream can be applied to fissures, and antibiotics are used to control footpad infections. Most dogs will live happy, comfortable lives with continuous, ongoing management of their feet to control the signs of this disorder.
Research Citation(s): Drogemuller, M. A mutation in the FAM83G gene in dogs with hereditary footpad hyperkeratosis (HFH), (2014) PLoS Genet 10(5); e1004370.
Associated Breed(s): Kromfohrländer, Mixed Breed, Irish Terrier,