Ichthyosis (Great Dane) Overview
Ichthyosis (Great Dane)
US$ 94.00 RRP
US$ 85.00 REGISTERED USER PRICEADD TO CART
Category: Dermatologic - Associated with the skin
Gene: Solute carrier family 27 member 4 (SLC27A4) Chromosome 9
Variant Detected: Base Substitution c.1268G>A p.Arg417Gln
Severity: Scale 2 has a low degree of severity. It has mild effects and generally does not pose any significant health concerns, or is easily managed.
Mode of Inheritance: Autosomal Recessive
Test Overview: Macroscopically, all dogs showed generalized gray to yellow scaling and skin wrinkles on the head and all 4 extremities. Skin sections were histologically examined using hematoxylin and eosin, Heidenhain's Azan, and Sudan red III staining methods and by conducting the alcian blue/periodic acid Schiff (AB/PAS) reaction technique on sections.
Research Citation(s): Metzger, A Novel SLC27A4 Splice Acceptor Site Mutation in Great Danes with Ichthyosis. 2015, PLoS ONE 10(10): e0141514
Associated Breed(s): Great Dane, Mixed Breed,