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Ichthyosis (Great Dane) Overview

Ichthyosis (Great Dane)
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Category: Dermatologic - Associated with the skin

Gene: Solute carrier family 27 member 4 (SLC27A4) Chromosome 9

Variant Detected: Base Substitution c.1268G>A p.Arg417Gln

Severity: Scale 2 has a low degree of severity. It has mild effects and generally does not pose any significant health concerns, or is easily managed.

Mode of Inheritance: Autosomal Recessive

Test Overview: Macroscopically, all dogs showed generalized gray to yellow scaling and skin wrinkles on the head and all 4 extremities. Skin sections were histologically examined using hematoxylin and eosin, Heidenhain's Azan, and Sudan red III staining methods and by conducting the alcian blue/periodic acid Schiff (AB/PAS) reaction technique on sections.

Research Citation(s): Metzger, A Novel SLC27A4 Splice Acceptor Site Mutation in Great Danes with Ichthyosis. 2015, PLoS ONE 10(10): e0141514

Associated Breed(s): Great Dane,  Mixed Breed,