Post Operative Haemorrhage / Platelet Disorder (Mountain Dog Type) Overview
Post Operative Haemorrhage / Platelet Disorder (Mountain Dog Type)
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Category: Haemolymphatic - Associated with the blood and lymph
Gene: Purinergic receptor P2Y12 (P2RY12) on Chromosome 23
Variant Detected: Nucleotide Deletion c.517-519delCCT p.Cys172del
Severity: Scale 2 has a low degree of severity. It has mild effects and generally does not pose any significant health concerns, or is easily managed.
Mode of Inheritance: Autosomal Recessive
Test Overview: Affected dogs show no abnormalities on physical examination. Dog may go through life event, such as whelping, vaccinations, deworming or microchip implantation, with no reported problems. Excessive, severe and prolonged bleeding occurs after trauma or minor cut, nail trimming, or during eruption of adult teeth. Problems occur after operation. Mucous membranes appear as pale and dog is weak, with severe bruising around the incision line. Collection of peritoneal fluid and its examination reveals internal bleeding. Hematoma can be found within the body, and in one affected dog hematoma was present near 1 ovarian pedicle. Spontaneous bleeding is usually not encountered in affected dogs.
Research Citation(s): Boudreaux MK, et al. P2Y12 receptor gene mutation associated with postoperative hemorrhage in a Greater Swiss Mountain dog. (2011) Vet Clin Pathol 40(2);202-206.
Associated Breed(s): Greater Swiss Mountain Dog, Mixed Breed,