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Affected dogs show no abnormalities on physical examination. Dog may go through life event, such as whelping, vaccinations, deworming or microchip implantation, with no reported problems. Excessive, severe and prolonged bleeding occurs after trauma or minor cut, nail trimming, or during eruption of adult teeth. Problems occur after operation. Mucous membranes appear as pale and dog is weak, with severe bruising around the incision line. Collection of peritoneal fluid and its examination reveals internal bleeding. Hematoma can be found within the body, and in one affected dog hematoma was present near 1 ovarian pedicle. Spontaneous bleeding is usually not encountered in affected dogs.
Haemolymphatic - Associated with the blood and lymph
Purinergic receptor P2Y12 (P2RY12) on Chromosome 23
Nucleotide Deletion c.516_518del p.Cys172del
Low. This disease generally causes mild signs of disease, or can be quite easily treated/managed.
Mode of Inheritance:
Boudreaux MK, et al. P2Y12 receptor gene mutation associated with postoperative hemorrhage in a Greater Swiss Mountain dog. (2011) Vet Clin Pathol 40(2);202-206.
Associated Breed(s):Greater Swiss Mountain Dog, Mixed Breed,