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The Tyrosinase-Related Protein 1 (TYRP1) has a key role in the synthesis of eumelanin (black) pigment. It can cause black pigment to dilute to a brown colour. Brown can also be referred to as liver, chocolate or red depending on the breed. The TYRP1 test currently identifies 3 "brown" alleles referred to as bs (stop codon), bd (deletion) and bc (insertion).
Please Note: In some breeds which are "visually" chocolate/brown the current test (variations) may not be detected.
Variants of the TYRP1 gene at the brown (B) Locus impact canine coat color by disrupting regular eumelanin (black pigment) synthesis which causes the dilution of black pigmented areas to brown. The B locus also controls the colour of the dog’s nose and foot pads regardless of the dog’s genotype at the E locus because eumelanin is still produced in the epidermis of the nose and foot pads of e/e dogs. Although black is dominant to brown, the overall B locus genotype for a dog is determined by the combination of the genotypes at the bc, bd and bs loci. The bc, bd, and bs variants confer brown coat, nose, and foot pads when at least one of these DNA changes is present on both genes of the dog at the B locus. If the dog has one or no copies of b then the dog will have a black coat, nose, and foot pads. However, the dog’s coat colour is also dependent on the E, K, and A genes among others.
Trait (Associated with Phenotype)
It is a trait and so is tested based on preference, not usually for health concerns.
Mode of Inheritance:
Mamm Genome. 2002 Jul;13(7):380-7.[PubMed 12140685]
Journal of Heredity 2005:96(4):289–301;
Heredity (2011) 106, 862–868;
"Conditions Associated with Coat Color in Dogs." University of Saskatchewan. University of Saskatchewan, 02 June 2011. Web. 03 Apr. 2014.
Dog Coat Colour Genetics http://doggenetics.co.uk/
Associated Breed(s):Affenpinscher, Afghan Hound, Airedale Terrier, Akita , Alaskan Husky, Alaskan Malamute, American Bulldog , American Bully , American Cocker Spaniel, American Eskimo Dog, American Foxhound, American Hairless (Rat) Terrier, American Pit Bull Terrier, American Staffordshire Terrier, Anatolian Shepherd, Asian Shepherd, Australasian Bosdog, Australian Bulldog, Australian Cattle Dog, Australian Cobberdog, Australian Kelpie, Australian Labradoodle , Australian Shepherd, Australian Silky Terrier, Australian Stumpy Tail Cattle Dog, Australian Terrier, Basenji, Basset Hound, Beagle, Bearded Collie , Bedlington Terrier, Belgian Groenendael Shepherd, Belgian Lakenois Shepherd, Belgian Malinois Shepherd, Belgian Tervueren Shepherd , Bernedoodle, Bernese Mountain Dog, Bichon Frise, Black Russian Terrier , Bloodhound, Boerboel, Border Collie, Border Terrier, Borzoi, Boston Terrier, Bouvier Des Flandres, Boxer , Boykin Spaniel, Bracco Italiano, Brazilian Terrier, Briard, British Bulldog, Brittany Spaniel , Bull Arab, Bull Terrier, Bullmastiff, Cairn Terrier, Canaan Dog, Cane Corso Italiano, Cardigan Welsh Corgi, Cardigan Welsh Corgi, Catahoula, Catahoula Leopard Dog, Cavador, Cavalier King Charles Spaniel, Cavoodle, Chesapeake Bay Retriever , Chihuahua, Chinese Crested, Chow Chow, Clumber Spaniel , Cockapoo, Cocker Spaniel, Collie Rough, Collie Smooth, Coonhound, Coton De Tulear, Curly Coated Retriever, Dachshund , Dachshund Standard Long Hair, Dachshund Standard Smooth Hair, Dachshund Standard Wire Hair, Dalmatian, Dandie Dinmont Terrier, Dingo, Dobermann, Dogue de Bordeaux, Dutch Shepherd, Dwarf Poodle, English Pointer, English Setter , English Shepherd, English Springer Spaniel, English Toy Spaniel , English Toy Terrier, Field Spaniel, Finnish Lapphund, Flat Coated Retriever, Fox Terrier (Toy), Foxhound , French Bulldog, German Pinscher, German Shepherd Dog, German Shorthaired Pointer, German Spitz , German Wirehaired Pointer, Giant Schnauzer, Glen of Imaal Terrier, Golden Retriever, Goldendoodle, Gordon Setter , Grand Basset Griffon Vendeen, Great Dane, Great Pyrenees, Greater Swiss Mountain Dog, Greyhound , Griffon Bruxellois - Standard, Groodle, Harlequin Pinscher, Havanese, Havanese Terrier Toy, Hungarian Kuvasz, Hungarian Vizsla, Huntaway, Ibizan Hound, Irish Setter, Irish Terrier, Irish Water Spaniel, Irish Wolfhound, Italian Greyhound, Italian Spinone, Jack Russell Terrier, Jagd Terrier, Japanese Chin, Japanese Shiba Inu, Japanese Spitz, Kaninchen Dachshund, Keeshond, Kerry Blue Terrier, Komondor, Koolie , Kromfohrländer, Labradoodle , Labradoodle Retrodoodle , Labrador Retriever, Lagotto Romagnolo, Lakeland Terrier , Lancashire Heeler, Landseer ECT, Lapponian Herder, Large Munsterlander, Leonberger, Lhasa Apso, Lowchen, Maltese, Manchester Terrier , Maremma Sheepdog, Mastiff , Miki, Miniature American Shepherd, Miniature Australian Bulldog, Miniature Bull Terrier, Miniature Dachshund Long Hair, Miniature Dachshund Smooth Hair, Miniature Dachshund Wire Hair, Miniature Fox Terrier, Miniature Pinscher , Miniature Poodle, Miniature Schnauzer, Miniature Yorkshire Terrier, Mixed Breed, Moodle, Mountain Dog , Moyen Poodle, Munsterlander, Murray River Retriever, Native American Indian Dog, Neapolitan Mastiff, New Zealand Heading Dog, Newfoundland, Norfolk Terrier , Norwegian Elkhound, Norwich Terrier, Nova Scotia Duck Tolling Retriever , Old Danish Pointing Dog, Old English Mastiff , Old English Sheepdog , Otterhound, Papillon, Parson Russell Terrier, Pekingese, Pembroke Welsh Corgi, Peruvian Hairless Dog, Petit Basset Griffon Vendeen, Phalene, Pharaoh Hound, Plott Hound, Pointer, Polish Lowland Sheepdog, Pomeranian, Portuguese Podengo, Portuguese Water Dog, Prague Ratter, Presa de Canario, Pug, Puli, Pumi, Rat Terrier, Red and White Setter, Rhodesian Ridgeback , Rottweiler , Russian Toy, Saint Bernard , Saluki, Samoyed, Sarplaninac, Schapendoes, Schipperke, Schnoodle, Scottish Deerhound, Scottish Terrier , Sealydale Terrier, Sealyham Terrier , Shar Pei, Shetland Sheepdog, Shiba Inu, Shih tzu, Short Bully, Shortybull, Siberian Husky, Siberian Husky, Silky Terrier , Skye Terrier, Sloughi, Smithfield, Smooth Fox Terrier, Soft Coated Wheaten Terrier, Spanish Water Dog, Spoodle, Staffordshire Bull Terrier , Standard Poodle, Standard Schnauzer, Sussex Spaniel, Swedish Lapphund, Swedish Vallhund, Tenterfield Terrier , Tibetan Mastiff, Tibetan Spaniel, Tibetan Terrier , Toy Poodle, Volpino Italiano, Water Spaniel , Weimaraner, Weimaraner Long Hair , Welsh Springer Spaniel, Welsh Terrier , West Highland White Terrier , Whippet , White Swiss Shepherd, Wire Fox Terrier, Wirehaired Vizsla, Xoloitzcuintle (Mexican Hairless), Yorkshire Terrier,