Brown Coat Colour Profile Overview
Brown Coat Colour Profile
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The Tyrosinase-Related Protein 1 (TYRP1) has a key role in the synthesis of eumelanin (black) pigment. It can cause black pigment to dilute to a brown colour. Brown can also be referred to as liver, chocolate or red depending on the breed. The TYRP1 test currently identifies 3 "brown" alleles referred to as bs (stop codon), bd (deletion) and bc (insertion).
Please Note: In some breeds which are "visually" chocolate/brown the current test (variations) may not be detected.
Category: Trait (Associated with Phenotype)
Severity: Scale 1 has a very low degree of severity. It is a trait and so is tested based on preference, not usually for health concerns.
Mode of Inheritance: Autosomal Recessive
Test Overview: Variants of the TYRP1 gene at the brown (B) Locus impact canine coat color by disrupting regular eumelanin (black pigment) synthesis which causes the dilution of black pigmented areas to brown. The B locus also controls the colour of the dog’s nose and foot pads regardless of the dog’s genotype at the E locus because eumelanin is still produced in the epidermis of the nose and foot pads of e/e dogs. Although black is dominant to brown, the overall B locus genotype for a dog is determined by the combination of the genotypes at the bc, bd and bs loci. The bc, bd, and bs variants confer brown coat, nose, and foot pads when at least one of these DNA changes is present on both genes of the dog at the B locus. If the dog has one or no copies of b then the dog will have a black coat, nose, and foot pads. However, the dog’s coat colour is also dependent on the E, K, and A genes among others.
Mamm Genome. 2002 Jul;13(7):380-7.[PubMed 12140685]
Journal of Heredity 2005:96(4):289–301;
Heredity (2011) 106, 862–868;
"Conditions Associated with Coat Color in Dogs." University of Saskatchewan. University of Saskatchewan, 02 June 2011. Web. 03 Apr. 2014.
Dog Coat Colour Genetics http://doggenetics.co.uk/
Associated Breed(s): Afghan Hound , Airedale Terrier, Akita , Alaskan Malamute, American Bulldog , American Cocker Spaniel, Australian Bulldog, Australian Cattle Dog, Australian Kelpie, Australian Silky Terrier, Basenji, Bassett Hound , Beagle, Bedlington Terrier, Bernese Mountain Dog, Black Russian Terrier , Border Collie, Border Terrier, Boston Terrier, Briard, British Bulldog, Brittany Spaniel , Griffon Bruxellois - Standard, Bull Terrier, Bullmastiff, Cairn Terrier, Cane Corso Italiano, Cardigan Welsh Corgi, Cavalier King Charles Spaniel, Chesapeake Bay Retriever , Chihuahua, Chinese Crested, Chow Chow, Clumber Spaniel , Cockapoo, Coton De Tulear, Curly Coated Retriever, Dachshund , Miniature Dachshund Long Hair, Miniature Dachshund Smooth Hair, Dalmatian, Dobermann, Dogue de Bordeaux, English Setter , English Springer Spaniel, Finnish Lapphund, Flat Coated Retriever, Smooth Fox Terrier, French Bulldog, German Shepherd Dog, Giant Schnauzer, Golden Retriever, Goldendoodle, Gordon Setter , Greyhound , Havanese, Irish Setter, Italian Greyhound, Jack Russell Terrier, Keeshond, Kerry Blue Terrier, Koolie , Labradoodle , Labrador Retriever, Lancashire Heeler, Landseer Newfoundland, Lapponian Herder, Lhasa Apso, Lowchen, Manchester Terrier , Mastiff , Miki, Newfoundland, Norfolk Terrier , Norwegian Elkhound, Norwich Terrier, Nova Scotia Duck Tolling Retriever , Old English Sheepdog , Papillon, Parson Russell Terrier, Pekingese, Plott Hound, German Shorthaired Pointer, Pomeranian, Toy Poodle, Miniature Poodle, Standard Poodle, Portuguese Water Dog, Great Pyrenees, Rat Terrier, Rhodesian Ridgeback , Rottweiler , Saluki, Samoyed, Schipperke, Scottish Terrier , Sealyham Terrier , Shar Pei, Shih tzu, Siberian Husky, Siberian Husky, Silky Terrier , Soft Coated Wheaten Terrier, Staffordshire Bull Terrier , Swedish Lapphund, Tenterfield Terrier , Tibetan Mastiff, Tibetan Spaniel, Tibetan Terrier , Volpino Italiano, Weimaraner, Cardigan Welsh Corgi, West Highland White Terrier , Whippet , Yorkshire Terrier, Affenpinscher, American Eskimo Dog, American Foxhound, American Staffordshire Terrier, Anatolian Shepherd, Australian Cobberdog, Australian Shepherd, Australian Stumpy Tail Cattle Dog, Australian Terrier, Bearded Collie , Belgian Groenendael Shepherd, Belgian Lakenois Shepherd, Belgian Malinois Shepherd, Belgian Tervueren Shepherd , Bichon Frise, Bloodhound, Boerboel, Borzoi, Bouvier Des Flandres, Boxer , Boykin Spaniel, Bull Arab, Canaan Dog, Catahoula, Catahoula Leopard Dog, Cavoodle, Cocker Spaniel, Collie Rough, Collie Smooth, Coonhound, Dandie Dinmont Terrier, Dingo, English Toy Spaniel , English Toy Terrier, Field Spaniel, Fox Terrier (Toy), Wire Fox Terrier, Foxhound , German Spitz , Great Dane, Groodle, Harlequin Pinscher, Havanese Terrier Toy, Hungarian Kuvasz, Hungarian Vizsla, Ibizan Hound, Irish Terrier, Irish Wolfhound, Italian Spinone, Jagd Terrier, Japanese Chin, Japanese Shiba Inu, Japanese Spitz, Komondor, Lagotto Romagnolo, Lakeland Terrier , Leonberger, Maltese, Maremma Sheepdog, Xoloitzcuintle (Mexican Hairless), Miniature Australian Shepherd, Miniature Bull Terrier, Miniature Dachshund Wire Hair, Miniature Fox Terrier, Miniature Pinscher , Miniature Schnauzer, Miniature Yorkshire Terrier, Mixed Breed, Mountain Dog , Munsterlander, Murray River Retriever, Neapolitan Mastiff, Old English Mastiff , Pembroke Welsh Corgi, Peruvian Hairless Dog, Pug, Puli, Saint Bernard , Schnoodle, Scottish Deerhound, Sealydale Terrier, Shetland Sheepdog, Shiba Inu, Skye Terrier, Sloughi, Smithfield, Spoodle, Standard Dachshund Long Hair, Standard Dachshund Smooth Hair, Standard Dachshund Wire Hair, Standard Schnauzer, Sussex Spaniel, Water Spaniel , Welsh Springer Spaniel, White Swiss Shepherd, American Bully , Australasian Bosdog, Australian Labradoodle , German Pinscher, Moodle, New Zealand Heading Dog, Old Danish Pointing Dog, Phalene, Swedish Vallhund, Welsh Terrier , Alaskan Husky, American Hairless (Rat) Terrier, Asian Shepherd, Bracco Italiano, Brazilian Terrier, Cavador, Dutch Shepherd, Dwarf Poodle, English Pointer, English Shepherd, German Wirehaired Pointer, Glen of Imaal Terrier, Grand Basset Griffon Vendeen, Greater Swiss Mountain Dog, Wirehaired Vizsla, Huntaway, Irish Water Spaniel, Kaninchen Dachshund, Kromfohrländer, Labradoodle Retrodoodle , Large Munsterlander, Native American Indian Dog, Otterhound, Petit Basset Griffon Vendeen, Pharaoh Hound, Pointer, Polish Lowland Sheepdog, Portuguese Podengo, Prague Ratter, Presa de Canario, Pumi, Red and White Setter, Russian Toy, Sarplaninac, Schapendoes, Short Bully, Shortybull, Spanish Water Dog, Weimaraner Long Hair , American Pit Bull Terrier, Miniature Australian Bulldog, Moyen Poodle, Bernedoodle,