Curly Coat Phenotype (KRT71) - SINGLE ASSAY TEST Overview
Curly Coat Phenotype (KRT71) - SINGLE ASSAY TEST
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Category: Trait (Associated with Phenotype)
Variant Detected: missense variant (c.451C>T, p.Arg151Trp)
Severity: Scale 1 has a very low degree of severity. It is a trait and so is tested based on preference, not usually for health concerns.
Mode of Inheritance: Autosomal Recessive
Test Overview: Hair shape, or curl, is an essential characteristic of a dog's coat and one of the most important traits in breed standards. Between the two extreme types of hair, straight and tightly curled, there is an array of intermediate types: loose curls, spiral shaped curls, waves, etc. Hair curls are most prominent on a long hair background, but their specific characteristics depend also on hair thickness, density, and the coat growth pattern. For instance, an insertion in the RSPO2 gene that is responsible for wiry hair and furnishings, produces wavy coats when it is expressed on a long hair background. When the RSPO2 mutation and the mutation associated with the curly hair trait segregate in a breed, as they do in the Portuguese Water Dog, a variety of coat types can be expected in the progeny: tight curls with furnishings, wavy coats without furnishings and flat coats with no obvious curls or waves.
Research Citation(s): A second KRT71 allele in curly coated dogs A. Bauer S. Hadji Rasouliha M. T. Brunner V. Jagannathan I. Bucher J. Bannoehr K. Varjonen R. Bond K. Bergvall M. M. Welle P. Roosje T. Leeb 1. Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, VonHoldt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, Andre C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA. Coat variation in the domestic dog is governed by variants in three genes. Science. 2009 Oct; 326(5949);150-153.
Associated Breed(s): Bichon Frise, Border Collie, Boykin Spaniel, Chesapeake Bay Retriever , Chihuahua, Dachshund , Havanese, Kerry Blue Terrier, Maltese, Portuguese Water Dog, Soft Coated Wheaten Terrier, Standard Poodle, Australian Labradoodle , Labradoodle , Labradoodle Retrodoodle , Australian Cobberdog,