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EM (MC1R) Locus - Melanistic Mask Overview

EM (MC1R) Locus - Melanistic Mask
US$ 75.00 RRP
US$ 67.50 REGISTERED USER PRICE
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Category: Trait (Associated with Phenotype)

Gene: MC1R

Variant Detected: Base Substitution G>A

Severity: Scale 1 has a very low degree of severity. It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance: Autosomal Recessive

Test Overview: The Em variant of the MC1R gene at the extension (E/e) Locus results in the localized distribution of eumelanin (black pigment) on the muzzle of the dog which resembles a dark "mask" on dogs with lighter colored coats. Although the Em variant produces a black melanistic mask, the final color of a dog's mask is dependent on other DNA variants such as the B and D loci that modify the production or appearance of the eumelanin (black pigment) in the dog. For example, dogs that are b/b at the B locus will have brown masks due to the disruption of eumelanin synthesis that results in the conversion of black pigmented areas to brown.

Research Citation(s):
"Conditions Associated with Coat Color in Dogs." University of Saskatchewan. University of Saskatchewan, 02 June 2011. Web. 03 Apr. 2014. .
Dog Coat Colour Genetics http://doggenetics.co.uk/
J Hered. 2003 Jan-Feb; 94(1):69-73. [PubMed: 12692165]
Animal Genetics. 2000 Jun; 31(3):194-99. [PubMed: 10895310]


Associated Breed(s): Afghan Hound ,  Akita ,  American Cocker Spaniel,  Australian Bulldog,  Belgian Malinois Shepherd,  Belgian Tervuren Shepherd ,  Boxer ,  Briard,  British Bulldog,  Bullmastiff,  Cairn Terrier,  Cardigan Welsh Corgi,  Cavalier King Charles Spaniel,  Chihuahua,  French Bulldog,  German Shepherd Dog,  Greyhound ,  Italian Greyhound,  Koolie ,  Pekingese,  Toy Poodle,  Miniature Poodle,  Standard Poodle,  Pug,  Saint Bernard ,  Saluki,  Staffordshire Bull Terrier ,  Tibetan Terrier ,  Cardigan Welsh Corgi,  Whippet ,  Affenpinscher,  Airedale Terrier,  Alaskan Malamute,  All Breeds (Canine),  American Bulldog ,  American Eskimo Dog,  American Foxhound,  American Staffordshire Terrier,  Anatolian Shepherd,  Australian Cattle Dog,  Australian Cobberdog,  Australian Kelpie,  Australian Shepherd,  Australian Silky Terrier,  Australian Stumpy Tail Cattle Dog,  Australian Terrier,  Basenji,  Bassett Hound ,  Beagle,  Bearded Collie ,  Bedlington Terrier,  Belgian Groenendael Shepherd,  Belgian Lakenois,  Bernese Mountain Dog,  Bichon Frise,  Black Russian Terrier ,  Bloodhound,  Boerboel,  Border Collie,  Border Terrier,  Borzoi,  Boston Terrier,  Bouvier Des Flandres,  Boykin Spaniel,  Brittany Spaniel ,  Bull Arab,  Bull Terrier,  Canaan Dog,  Cane Corso Italiano,  Catahoula,  Catahoula Leopard Dog,  Cavoodle,  Chesapeake Bay Retriever ,  Chinese Crested,  Chow Chow,  Clumber Spaniel ,  Cockapoo,  Cocker Spaniel,  Collie Rough,  Collie Smooth,  Coonhound,  Coton De Tulear,  Curly Coated Retriever,  Dachshund ,  Dalmatian,  Dandie Dinmont Terrier,  Dingo,  Dobermann,  Dogue de Bordeaux,  English Setter ,  English Springer Spaniel,  English Toy Spaniel ,  English Toy Terrier,  Field Spaniel,  Finnish Lapphund,  Flat Coated Retriever,  Fox Terrier ,  Fox Terrier (Toy),  Wire Fox Terrier,  Foxhound ,  German Shorthaired Pointer,  German Spitz ,  Giant Schnauzer,  Golden Retriever,  Goldendoodle,  Gordon Setter ,  Great Dane,  Great Pyrenees,  Griffon Bruxellois - Standard,  Groodle,  Harlequin Pinscher,  Havanese,  Havanese Terrier Toy,  Hungarian Kuvasz,  Hungarian Vizsla,  Ibizan Hound,  Irish Setter,  Irish Terrier,  Irish Wolfhound,  Italian Spinone,  Jack Russell Terrier,  Jagd Terrier,  Japanese Chin,  Japanese Shiba Inu,  Japanese Spitz,  Keeshond,  Kerry Blue Terrier,  Komondor,  Labradoodle ,  Labrador Retriever,  Lagotto Romagnolo,  Lakeland Terrier ,  Lancashire Heeler,  Landseer Newfoundland,  Lapponian Herder,  Leonberger,  Lhasa Apso,  Lowchen,  Maltese,  Manchester Terrier ,  Maremma Sheepdog,  Mastiff ,  Mexican Hairless ,  Miki,  Miniature Australian Shepherd,  Miniature Bull Terrier,  Miniature Dachshund Long Hair,  Miniature Dachshund Smooth Hair,  Miniature Dachshund Wire Hair,  Miniature Fox Terrier,  Miniature Pinscher ,  Miniature Schnauzer,  Miniature Yorkshire Terrier,  Mixed Breed,  Mountain Dog ,  Munsterlander,  Murray River Retriever,  Neopolitan Mastiff,  Newfoundland,  Norfolk Terrier ,  Norwegian Elkhound,  Norwich Terrier,  Nova Scotia Duck Tolling Retriever ,  Old English Mastiff ,  Old English Sheepdog ,  Papillon,  Parson Russell Terrier,  Pembroke Welsh Corgi,  Peruvian Hairless Dog,  Plott Hound,  Pomeranian,  Portuguese Water Dog,  Puli,  Rat Terrier,  Rhodesian Ridgeback ,  Rottweiler ,  Samoyed,  Schipperke,  Schnoodle,  Scottish Deerhound,  Scottish Terrier ,  Sealydale Terrier,  Sealyham Terrier ,  Shar Pei,  Shetland Sheepdog,  Shiba Inu,  Shih tzu,  Siberian Husky,  Silky Terrier ,  Skye Terrier,  Sloughi,  Smithfield,  Soft Coated Wheaten Terrier,  Spoodle,  Standard Dachshund Long Hair,  Standard Dachshund Smooth Hair,  Standard Dachshund Wire Hair,  Standard Schnauzer,  Sussex Spaniel,  Swedish Lapphund,  Tenterfield Terrier ,  Tibetan Mastiff,  Tibetan Spaniel,  Volpino Italiano,  Water Spaniel ,  Weimaraner,  Welsh Springer Spaniel,  West Highland White Terrier ,  White Swiss Shepherd,  Yorkshire Terrier,