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Weight and Appetite Obesity Prone Overview

Weight and Appetite Obesity Prone
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Category: Trait (Associated with Phenotype)

Gene: POMC

Variant Detected: The POMC mutation is a 14 base pair deletion in the 3rd-4th exon of the POMC gene.

Severity: Scale 2 has a low degree of severity. It has mild effects and generally does not pose any significant health concerns, or is easily managed.

Mode of Inheritance: Autosomal Recessive

Test Overview: The prevalence of overweight or obese dogs in domesticated canine populations has been reported to range between 23 - 41% [1]. In Australia, a survey of 428 vet practices revealed that 41% of surveyed dogs were considered overweight or obese [2]. The Labrador retriever is one of the most documented breeds for obesity prevalence [3-5].To date, two studies have reported an association between the POMC mutation and weight in Labrador retrievers [6,7]. However, it is important to note that both the studies (Raffan et al n=310 and Mankowska et al. n=126) used relatively small populations of Labrador retrievers, thus the effect of this mutation is not definitive.

Research Citation(s): 1. Lund et al. Intern J Appl Res Vet Med • Vol. 4, No. 2, 2006 page 177-186 2. McGreevy et al. Veterinary Record (2005) 156, 695-702 3. Edney and Smith, Vet. Rec., 118 (1986), pp. 391-396 4. O’Neill et al . PLoS ONE, 9 (2014), p. e90501 5. Mason et al. Veterinary Record (1970) 86, 612-616 6. Raffan et al. Cell Metabolism (2016) 23, 893–900 7. Mankowska et al. Res Vet Sci (2017) 112, 116-118

Associated Breed(s): Labrador Retriever,  Labradoodle Retrodoodle ,  Labradoodle ,  Mixed Breed,  Cavador,  Australian Cobberdog,  Australian Labradoodle ,