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Cardiomyopathy and Juvenile mortality (CJM) is a poorly defined systemic disease.
Affected puppies die at birth or at a maximum age of 6-8 weeks.
In a recently reported case, the puppies initially developed normally but then showed non-specific symptoms like vomiting, uncoordinated movements, trembling or respiratory symptoms and died a few days after the first clinical signs, usually due to heart failure.
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Associated Breed(s):
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Category:
Genetic Diseases
Severity:
Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.
Gene:
YARS2, chr13
Variant Detected:
c.1054G>A p.Glu352Lys
Mode of Inheritance:
Recomended Screening:
Research Citation(s):