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The skeletal dysplasias are disorders of the bone and cartilage tissues.
Similarly to humans, several dog breeds have been reported to suffer from different types of genetic skeletal disorders.
We have studied the molecular genetic background of an autosomal recessive chondrodysplasia that affects the Norwegian Elkhound and Karelian Bear Dog breeds.
The affected dogs suffer from disproportionate short stature dwarfism of varying severity.
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Associated Breed(s):
Click here to view Associated Breeds
Category:
Genetic Diseases
Severity:
Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.
Gene:
Integrin subunit alpha 10 (ITGA10) on Chromosome 17
Variant Detected:
Base Substitution c.2083C>T p.Arg695STOP
Mode of Inheritance:
Recomended Screening:
Research Citation(s):