Dystrophic epidermolysis bullosa (DEB) is a hereditary skin disease affecting dogs.

The disease is characterized by blisters and erosions in the oral and esophageal epithelia, together with milia, nails dystrophy and growth retardation.

Clinical signs of DEB are present at birth.

Affected dogs have fragile skin that is easily damaged from rubbing or trauma resulting in blisters, ulcers and scarring of the skin.

Areas that are most prone to blisters are the face, foot pads, genital areas and ears.