Autoimmune Lymphoproliferative Syndrome - SINGLE ASSAY TEST Overview
Autoimmune Lymphoproliferative Syndrome - SINGLE ASSAY TEST
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Category: Immunologic - Associated with the organs and cells of the immune system
Variant Detected: c.413-414InsA
Severity: Scale 5 is the most extreme in severity. It comprises rapidly fatal diseases that may also cause a significant decrease in the quality of life.
Mode of Inheritance: Autosomal Recessive
Test Overview: This disease is characterised by a build up of immune cells on the spleen and lymph nodes. Symptoms tend to be seen at around 6 to 8 weeks and progression tends to be quite rapid after that. Affected kittens show abdominal distension, tend to be lethargic and show weight loss due to anaemia.
Research Citation(s): 1Aberdein D, Munday JS, Gandolfi B, Dittmer KE, Malik R, Garrick DJ, Lyons LA & 99 Lives Consortium (2017). A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats. Mammalian Genome 28, 47- 55. Aberdein D, Munday JS, Fairly RA, Vernau W & Thompson KG (2015). A novel and likely inherited lymphoproliferative disease in British Shorthair kittens. Veterinary Pathology 52, 1176-1182.
Associated Breed(s): British Shorthair,