Autoimmune Lymphoproliferative Syndrome - SINGLE ASSAY TEST Overview

Autoimmune Lymphoproliferative Syndrome - SINGLE ASSAY TEST
US$ 75.00 RRP

Category: Immunologic - Associated with the organs and cells of the immune system

Gene: FASL

Variant Detected: c.413-414InsA

Severity: Scale 5 is the most extreme in severity. It comprises rapidly fatal diseases that may also cause a significant decrease in the quality of life.

Mode of Inheritance: Autosomal Recessive

Test Overview: This disease is characterised by a build up of immune cells on the spleen and lymph nodes. Symptoms tend to be seen at around 6 to 8 weeks and progression tends to be quite rapid after that. Affected kittens show abdominal distension, tend to be lethargic and show weight loss due to anaemia.

Research Citation(s): 1Aberdein D, Munday JS, Gandolfi B, Dittmer KE, Malik R, Garrick DJ, Lyons LA & 99 Lives Consortium (2017). A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats. Mammalian Genome 28, 47- 55. Aberdein D, Munday JS, Fairly RA, Vernau W & Thompson KG (2015). A novel and likely inherited lymphoproliferative disease in British Shorthair kittens. Veterinary Pathology 52, 1176-1182.

Associated Breed(s): British Shorthair,  British Longhair,