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ABCB4 functions as a phosphatidylcholine translocater, flipping phosphatidylcholine across hepatocyte canalicular membranes into biliary canaliculi.
Hepatobiliary disease in dogs has been recognized with increased frequency during the past several years.
In particular, gallbladder mucoceles (mucinous hyperplasia or mucinous cholecystitis) have been documented to be an increasingly important cause of hepatobiliary disease in dogs.
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Associated Breed(s):
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Category:
Genetic Diseases
Severity:
Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.
Gene:
ABCB4
Variant Detected:
Insertion of G
Mode of Inheritance:
Recomended Screening:
Research Citation(s):