Dogs with variations in both copies of the SLC2A9 gene(variant) are predisposed to have elevated levels of uric acid in the urine, hence the name hyperuricosuria.

Uric acid can form crystals and/or stones (uroliths) in the urinary tract.

Dogs with hyperuricosuria most commonly present with symptoms of recurrent urinary tract inflammation, which include frequent urination, blood in the urine, and straining to urinate.

They may also have loss of appetite, lethargy, weakness, vomiting and pain.

Urinary stones in the bladder can cause urinary tract infections or more seriously, blockage of the Urethra.

Both male and female dogs can be affected, but obstruction of urine flow is more common in males due to differences in anatomy.