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Dog ichthyosis a hereditary, monogenic, cornification disorder, appearing early and persisting for life.
Cornification disorders form a heterogeneous group of diseases characterised by abnormal differentiation (cornification) of the epidermis.
Theichthyoses, a member of this group, are distinguishable clinically by generalised scaling and histopathologically, in most cases, by a thickened stratum corneum.
In veterinary medicine, ichthyosis is now commonly classified into either epidermolytic or non-epidermolytic subtypes.
Most reported cases in dogs are non-epidermolytic with heterogeneous clinical, histopathological and ultrastructural profiles.
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Associated Breed(s):
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Category:
Genetic Diseases
Severity:
Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.
Gene:
Keratin 10 (KRT10) on Chromosome 9
Variant Detected:
Base Substitution c.1125 + 1 G>T p. exon5/intron5 splice site
Mode of Inheritance:
Recomended Screening:
Research Citation(s):