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The original paper by Donner et al (2016); found this mutation to be polymorphic in several breeds, suggesting that it is not the causative variant.
This result is not recommended for breeding decisions.
$ 50.00
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Associated Breed(s):
Click here to view Associated Breeds
Category:
Genetic Diseases
Severity:
Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.
Gene:
von Willebrand factor (vWF) on Chromosome 27
Variant Detected:
Base Substitution c.4937A>G p.Asn883Ser
Mode of Inheritance:
Recomended Screening:
1. DNA testing of all breeding animals performed prior to breeding – e.g. at 1 year of age. 2. Recommend DNA testing prior to any surgery (e.g. desexing). Can perform DNA test on puppies (e.g. at 8-12 weeks). 3. Alternatively recommend coagulation testing with BMBT (not PT/APTT) prior to desexing or routine surgery (As DNA test available for a few breeds only)
Research Citation(s):