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Acute Respiratory Distress Syndrome (Dalmatian Type) Overview

Acute Respiratory Distress Syndrome (Dalmatian Type)
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Category: Respiratory - Associated with the lungs and respiratory system

Gene: Anillin actin binding protein (ANLN) on chromosome 14

Variant Detected: Base Substitution c.31C>T p.Arg11STOP

Severity: Scale 3 has a moderate degree of severity, as it is not a fatal disease, though it can decrease the quality of life.

Mode of Inheritance: Autosomal Recessive

Test Overview: Acute respiratory distress syndrome (ARDS) is the leading cause of death in critical care medicine. The syndrome is typified by an exaggerated inflammatory response within the lungs. ARDS has been reported in many species, including dogs. It has been reported a fatal familial juvenile respiratory disease accompanied by occasional unilateral renal aplasia and hydrocephalus, in Dalmatian dogs.

Research Citation(s): Holopainen, S et al. ANLN truncation causes a familial fatal acute respiratory distress syndrome in Dalmatian dogs. (2017) PLoS Genet 13;2, e1006625

Associated Breed(s): Dalmatian,  Mixed Breed,