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Adult Onset Deafness Border Collie (Linkage Association Research Test) - SINGLE ASSAY TEST

US$ 40.00 RRP

US$ 40.00 (USER PRICE)

Description:

This test is currently offered as 'research only' and results should not to be used for making key breeding decisions.  We are working to try and gather data on Border Collie populations with a key focus on Australian show and working lines. Please Note: The price advertised covers laboratory costs associated with running this test.  Results will be issued with any samples submitted.

Test Overview:

Domestic dogs can suffer from hearing losses that can have profound impacts on working ability and quality of life. We have identified a type of adult-onset hearing loss in Border Collies that appears to have a genetic cause, with an earlier age of onset (3–5 years) than typically expected for ageing dogs (8–10 years).

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

USP31

Variant Detected:

c.846+5 T>G

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Complex - Mode Unknown

Research Citation(s):

Yokoyama, 2019, PLoS Genet 8(9): e1002898
2014 Schmutz, S.M. : An analysis of the inheritance pattern of an adult-onset hearing loss in Border Collie dogs. Canine Genet Epidemiol 1:6, 2014. Pubmed reference: 26401323. DOI: 10.1186/2052-6687-1-6.
2012 Yokoyama, J.S., Lam, E.T., Ruhe, A.L., Erdman, C.A., Robertson, K.R., Webb, A.A., Williams, D.C., Chang, M.L., Hytönen, M.K., Lohi, H., Hamilton, S.P., Neff, M.W. : Variation in genes related to cochlear biology is strongly associated with adult-onset deafness in border collies. PLoS Genet 8:e1002898, 2012. Pubmed reference: 23028339. DOI: 10.1371/journal.pgen.1002898.

Associated Breed(s):

Border Collie,