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COVID 19 UPDATE - our AUS and US offices & genetic testing laboratories remain open.We realise that things are changing quickly, but we remain operating as usual.We will keep up you updated even as other restrictions to different services are introduced.

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Arrhythmogenic Right Ventricular Cardiomyopathy (Boxer Type)

US$ 75.00 RRP

US$ 50.00 (USER PRICE)

Test Overview:

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease characterized by ventricular arrhythmias and sudden cardiac death. It is most frequently inherited as an autosomal dominant trait with incomplete and age-related penetrance and variable clinical expression.

Category:

Cardiovascular - Associated with the heart and blood vessels

Gene:

Striatin (STRN) on chromosome 17

Variant Detected:

Nucleotide deletion chr17:29269446-29272662 deletion CATACACA (canFam3) 3’Untranslated region of the STRN gene

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Dominant with Incomplete Penetrance

Research Citation(s):

Meurs KM et al. Genome-wide association identifies a deletion in the 30 untranslated region of Striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy. (2010), Hum Genet, 128, 315–324.

Associated Breed(s):

Boxer , Mixed Breed,