Canine Hyperuricosuria Overview
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Category: Urinary system / Urologic - Associated with the kidneys, bladder, ureters and urethra
Gene: Solute carrier family 2 member 9 (SLC2A9) on chromosome 3
Variant Detected: Base Substitution c.563G>T p.Cys188Phe
Severity: Scale 3 has a moderate degree of severity, as it is not a fatal disease, though it can decrease the quality of life.
Mode of Inheritance: Autosomal Recessive
Test Overview: Dogs with variations in both copies of the SLC2A9 gene(variant) are predisposed to have elevated levels of uric acid in the urine, hence the name hyperuricosuria. Uric acid can form crystals and/or stones (uroliths) in the urinary tract. Dogs with hyperuricosuria most commonly present with symptoms of recurrent urinary tract inflammation, which include frequent urination, blood in the urine, and straining to urinate. They may also have loss of appetite, lethargy, weakness, vomiting and pain. Urinary stones in the bladder can cause urinary tract infections or more seriously, blockage of the Urethra. Both male and female dogs can be affected, but obstruction of urine flow is more common in males due to differences in anatomy.
Research Citation(s): Bannasch D, et al. Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog. (2008), PLOS genet, 4;11,e1000246 Bannasch, D., Young, A., Myers, J., Truve, K., Dickinson, P., Gregg, J., Davis, R., Bongcam-Rudloff, E., Webster, M.T., Lindblad-Toh, K., Pedersen, N. : Localization of canine brachycephaly using an across breed mapping approach. PLoS One 5:e9632, 2010. Pubmed reference: 20224736. DOI: 10.1371/journal.pone.0009632.
Associated Breed(s): American Bulldog , Australian Bulldog, Black Russian Terrier , British Bulldog, Dalmatian, French Bulldog, German Shepherd Dog, Giant Schnauzer, Jack Russell Terrier, Koolie , Labradoodle , Labrador Retriever, Parson Russell Terrier, Pomeranian, Weimaraner, White Swiss Shepherd, Mixed Breed, Harlequin Pinscher, Lagotto Romagnolo, Swedish Vallhund, Large Munsterlander, Anatolian Shepherd, Miniature Australian Shepherd, Short Bully, Shortybull, American Bully , Hungarian Vizsla, American Pit Bull Terrier, Australian Cobberdog, Australian Labradoodle , Labradoodle Retrodoodle , Groodle, Australian Shepherd,