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Canine Leucocyte Adhesion Deficiency Type III (German Shepherd Type) Overview

Canine Leucocyte Adhesion Deficiency Type III (German Shepherd Type)
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Category: Immunologic - Associated with the organs and cells of the immune system

Gene: FERMT3

Variant Detected: 12bp insertion

Severity: Scale 4 has a high degree of severity. It generally causes a decreased quality of life and may also decrease the life expectancy.

Mode of Inheritance: Autosomal Recessive

Test Overview: Symptoms include recurrent infections, neonatal omphalophlebitis, fever, anorexia, lameness, impaired wound healing, severe skin infections, gingivitis, salivation, thickened mandible, enlarged metaphyses of the distal radius, ulna, tibia, and fibula, lameness, enlarged lymph nodes, and low body weight. Onset of signs is often around 10 weeks of age, with average age of presentation to the veterinarian at 13.5 weeks.

Research Citation(s): 2014 Hugo, T.B., Heading, K.L. : Leucocyte adhesion deficiency III in a mixed-breed dog. Aust Vet J 92:299-302, 2014. Pubmed reference: 24954630. DOI: 10.1111/avj.12206.
2010 Boudreaux, MK., Wardrop, KJ., Kiklevich, V., Felsburg, P., Snekvik, K. : A mutation in the canine Kindlin-3 gene associated with increased bleeding risk and susceptibility to infections. Thromb Haemost 103:475-7, 2010. Pubmed reference: 20126836. DOI: 10.1160/TH09-09-0571.


Associated Breed(s): German Shepherd Dog,  Mixed Breed,  White Swiss Shepherd,