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Cerebellar cortical degeneration (CCD) is an increasingly recognised neurodegenerative disease process affecting many dog breeds. Typical presentation consists of a progressive cerebellar ataxia, with a variable age at onset and rate of progression between different breeds. Cerebellar histopathological findings typically consist of primary Purkinje neuronal degeneration and loss, with variable secondary depletion of the granular and molecular cell layers. Causative genes have been identified associated with CCD in several breeds, allowing screening for selective breeding to reduce the prevalence of these conditions.
Nervous system / Neurologic - Associated with the brain, spinal cord and nerves
8 base pair deletion TCAAGGCA
Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.
Mode of Inheritance:
Vet Rec. 2014 Mar 29;174(13):334. doi: 10.1136/vr.g2347.
Associated Breed(s):Hungarian Vizsla, Mixed Breed,