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Cerebellar Cortical Degeneration (Hungarian Vizsla Type) Overview

Cerebellar Cortical Degeneration (Hungarian Vizsla Type)
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Category: Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene: SPTBN2

Variant Detected: 8 base pair deletion TCAAGGCA

Severity: Scale 5 is the most extreme in severity. It comprises rapidly fatal diseases that may also cause a significant decrease in the quality of life.

Mode of Inheritance: Autosomal Recessive

Test Overview: : Cerebellar cortical degeneration (CCD) is an increasingly recognised neurodegenerative disease process affecting many dog breeds. Typical presentation consists of a progressive cerebellar ataxia, with a variable age at onset and rate of progression between different breeds. Cerebellar histopathological findings typically consist of primary Purkinje neuronal degeneration and loss, with variable secondary depletion of the granular and molecular cell layers. Causative genes have been identified associated with CCD in several breeds, allowing screening for selective breeding to reduce the prevalence of these conditions.

Research Citation(s): Vet Rec. 2014 Mar 29;174(13):334. doi: 10.1136/vr.g2347.

Associated Breed(s): Hungarian Vizsla,  Mixed Breed,