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Congenital Hypothyroidism with Goiter (Toy Fox Terrier Type) Overview

Congenital Hypothyroidism with Goiter (Toy Fox Terrier Type)
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US$ 67.50 REGISTERED USER PRICE
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Category: Haemolymphatic (Associated with the Circulatory System)

Gene: Thyroid peroxidase (TPO) on chromosome 17

Variant Detected: Base Substitution c.331C>T p.Arg111STOP

Severity: Scale 4 has a high degree of severity. It generally causes a decreased quality of life and may also decrease the life expectancy.

Mode of Inheritance: Autosomal Recessive

Test Overview: Congenital hypothyroidism (CH) may be caused by inherited defects or by exposure of the fetus or newborn to iodine excess or deficiency. Neonatal affected pups exhibited inactivity, abnormal hair coat, stenotic ear canals, and delayed eye opening. Palpable ventrolateral cervical swellings were evident by 1 week of age. Serum thyroid hormone and thyroid-stimulating hormone concentrations were low and high, respectively.

Research Citation(s): Fyfe JC, et al. Congenital Hypothyroidism with Goiter in Toy Fox Terrier. (2003) J Vet Intern Med,17;50–57.

Associated Breed(s): Fox Terrier (Toy),  Rat Terrier,  Mixed Breed,