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Exercise Induced Collapse (Retriever Type) Overview

Exercise Induced Collapse (Retriever Type)
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Category: Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene: DNM1

Variant Detected: Base Substitution c.767 G>T

Severity: Scale 3 has a moderate degree of severity, as it is not a fatal disease, though it can decrease the quality of life.

Mode of Inheritance: Autosomal Recessive with Incomplete Penetrance

Test Overview: This is an autosomal recessive condition that affects Labradors, as well as several other related breeds. The condition is also seen in mixed breeds, mainly Labrador crosses. The condition is not common, although it is estimated up to 35% of the Labrador population (in the USA) may be carriers of the gene mutation that causes the disease (ie mutation of the dynamin-1 gene). Signs are usually first seen in young adults, between 6 months and 3 years of age. With vigorous exercise lasting 5-20 minutes, a loss of control becomes apparent in the hind limbs. Starting as a wobbly gait, the loss of control progresses to collapse, and sometimes dogs may seem confused. Occasional deaths have been reported, so it is important that exercise is stopped as soon as signs first appear. Excitement and high temperatures and/or humidity may exacerbate signs. There are sporadic reports of various supplements having some positive effect in a small number of dogs, as well as one report of sub-anticonvulsant doses of phenobarbitone being useful in some severely affected dogs; however there is currently no proven reliable cure or treatment for this disease. All affected animals should be withdrawn from work and should avoid situations involving excitement and/or stress.  

Recommended Screening: DNA test available for dynamin-1 mutation, recommend screen all breeding animals by 1 year of age.

Research Citation(s): Furrow E, Minor KM, Taylor SM, Mickelson JR, Patterson EE. Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers. J Am Vet Med Assoc. 2013 Mar 15;242(6):786-91. [PubMed: 23445289] Minor KM, Patterson EE, Keating MK, Gross SD, Ekenstedt KJ, Taylor SM, Mickelson JR. Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds. Vet J. 2011 Aug; 189(2):214-9. [PubMed: 21782486] Patterson EE, Minor KM, Tchernatynskaia AV, Taylor SM, Shelton GD, Ekenstedt KJ, Mickelson JR. A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Nat Genet. 2008 Oct; 40(10):1235-9. [PubMed: 18806795] Taylor SM, Shmon CL, Adams VJ, Mickelson JR, Patterson EN, Shelton GD. Evaluations of labrador retrievers with exercise-induced collapse, including response to a standardized strenuous exercise protocol. J Am Anim Hosp Assoc. 2009 Jan-Feb; 45(1):3-13. [PubMed: 19122058] Taylor SM, Shmon CL, Shelton GD, Patterson EN, Minor K, Mickelson JR. Exercise-induced collapse of Labrador retrievers: survey results and preliminary investigation of heritability. J Am Anim Hosp Assoc. 2008 Nov-Dec; 44(6):295-301. [PubMed: 18981194]

Associated Breed(s): American Cocker Spaniel,  Bouvier Des Flandres,  Boykin Spaniel,  Chesapeake Bay Retriever ,  Clumber Spaniel ,  Curly Coated Retriever,  Labradoodle ,  Labrador Retriever,  Old English Sheepdog ,  Pembroke Welsh Corgi,  Mixed Breed,  German Wirehaired Pointer,  Australian Labradoodle ,  Australian Cobberdog,  Cavador,  Labradoodle Retrodoodle ,  Cocker Spaniel,  Hungarian Vizsla,  Cardigan Welsh Corgi,