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Factor VII Deficiency Overview

Factor VII Deficiency
US$ 75.00 RRP
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Category: Haemolymphatic (Associated with the Circulatory System)

Gene: Coagulation factor VII (F7) Chromosome 22

Variant Detected: Base Substitution c.407G>A p.Gly136Glu

Severity: Scale 3 has a moderate degree of severity, as it is not a fatal disease, though it can decrease the quality of life.

Mode of Inheritance: Autosomal Recessive

Test Overview: Factor VII deficiency is a blood clotting disorder that causes excessive or prolonged bleeding after an injury or surgery. With factor VII deficiency, your body either doesn’t produce enough factor VII, or something is interfering with your factor VII, often another medical condition. Factor VII is a protein produced in the liver that plays an important role in helping your blood to clot. It’s one of about 20 clotting factors involved in the complex process of blood clotting. To understand factor VII deficiency, it helps to understand the role factor VII plays in normal blood clotting.

Research Citation(s): Callan MB, et al. A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. (2006) J Thromb Haemost. 4: 2616–22.

Associated Breed(s): Beagle,  Giant Schnauzer,  Miniature Schnauzer,  Scottish Deerhound,  Papillon,  Mixed Breed,