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Old English Sheepdogs and Gordon Setters suffer from a juvenile onset, autosomal recessive form of canine hereditary ataxia primarily affecting the Purkinje neuron of the cerebellar cortex. The clinical and histological characteristics are analogous to hereditary ataxias in humans. Linkage and genome-wide association studies on a cohort of related Old English Sheepdogs identified a region on CFA4 strongly associated with the disease phenotype.
Nervous system / Neurologic - Associated with the brain, spinal cord and nerves
RAB24, member RAS oncogene family on Chromosome 4
Base Substitution c.113A>C p.Gln38Pro
Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.
Mode of Inheritance:
Agler C, et al. Canine hereditary ataxia in old english sheepdogs and gordon setters is associated with a defect in the autophagy gene encoding RAB24. (2014) PLoS Genet 10(2);e1003991.
Associated Breed(s):Gordon Setter , Mixed Breed, Old English Sheepdog ,