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Hip Dysplasia German Shepherd Type (RESEARCH ONLY) - SINGLE ASSAY TEST

US$ 40.00 RRP

US$ 40.00 (USER PRICE)

Description:

This test is currently offered as 'research only' (not a risk associated test) and results should not to be used for making key breeding decisions.  We are working to try and gather data on German Shepherd populations both show and working lines. Please Note: The price advertised covers laboratory costs associated with running this test.  Results will be issued with any samples submitted.  The research group that has published the science is not affiliated in anyway with Orivet and the test offered.

Test Overview:

Hip dysplasia is a developmental problem of the hip joint that causes “loose” hip joints (hip joint laxity) and leads to degenerative joint disease (arthritis). It occurs in many dog breeds, and there is a genetic predisposition to develop this condition, but the mode of inheritance is complex, and involves many genes (polygenic). Development of the disease is also influenced by environmental factors as well as body size and conformation, with larger dogs having a higher incidence of the condition, including many breeds that are heavily built. Because of the complexity of the genetics associated with canine hip dysplasia, normal parents can still produce affected offspring. Hip dysplasia can be painful as early as 5-10 months of age, and affected dogs may have trouble with walking up stairs, or show stiffness after exercise. It is more common that no signs are seen when the dog is young, but pain develops as the dog gets older. This is because the hip joint is loose, and the bony structure of the joint becomes altered in an attempt to compensate and stabilise the joint. This is known as arthritis, and it causes pain and restriction of movement of affected joints. Pain can become very severe or crippling as the dog ages and as arthritic changes become ever more severe. Often this joint pain will be worse in cold weather. Keeping your dog at a healthy weight, providing gentle or non-weight bearing exercise (e.g. swimming or walking in chest-deep water) and a warm, padded bed at night can all help with arthritic pain, as well as several supplements and medications that your vet may prescribe to aid in joint repair and to provide pain relief. Installing ramps in place of steps at home is another great way to help your arthritic dog, as is placing food and water bowls where they can be easily accessed and providing a warm coat in winter. While treatment usually involves medication and lifestyle changes, surgical treatment can be performed in young animals to attempt place the head of the femur more tightly within the hip, but this treatment is of no use to the adult animal with arthritic pain. In smaller animals, removing the head of the femur may relieve pain, but larger animals (who more commonly develop this condition) usually do not cope well with this type of surgery. Total hip replacement is generally considered the surgical procedure of choice in the larger patient. The genetic background of hip dysplasia in dogs remained ambiguous despite rigorous studies. This DNA test is based on studies which performed genetic analyses with carefully phenotyped case-control cohorts comprising 525 German Shepherd dogs. The study revealed DNA deletions of variable sizes in a putative enhancer element of the NOG gene. NOG encodes for noggin, a well-described bone morphogenetic protein inhibitor affecting multiple developmental processes, including joint development. The deletion was associated with the healthy controls and mildly dysplastic dogs suggesting a protective role against canine hip dysplasia.

Category:

Musculoskeletal - Associated with muscles, bones and associated structures

Gene:

NOG-Noggn chromosome 9

Variant Detected:

deletion chr9:31453837–31453860

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Complex - Mode Unknown

Research Citation(s):

https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008197

Associated Breed(s):

German Shepherd Dog, White Swiss Shepherd,