Ichthyosis (Norfolk Terrier) Overview
Ichthyosis (Norfolk Terrier)
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Category: Dermatologic - Associated with the skin
Gene: Keratin 10 (KRT10) on Chromosome 9
Variant Detected: Base Substitution c.1125 + 1 G>T p. exon5/intron5 splice site
Severity: Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.
Mode of Inheritance: Autosomal Recessive
Test Overview: Dog ichthyosis a hereditary, monogenic, cornification disorder, appearing early and persisting for life. Cornification disorders form a heterogeneous group of diseases characterised by abnormal differentiation (cornification) of the epidermis. Theichthyoses, a member of this group, are distinguishable clinically by generalised scaling and histopathologically, in most cases, by a thickened stratum corneum. In veterinary medicine, ichthyosis is now commonly classified into either epidermolytic or non-epidermolytic subtypes. Most reported cases in dogs are non-epidermolytic with heterogeneous clinical, histopathological and ultrastructural profiles.
Research Citation(s): Credille KM, et al. Mild recessive epidermolytic hyperkeratosis associated with a novel keratin 10 donor splice-site mutation in a family of Norfolk terrier dogs.(2005) Br J Dermatol, 153;51-58.
Associated Breed(s): Norfolk Terrier , Mixed Breed,