O-Store

Platelet Dysfunction Overview

Platelet Dysfunction
US$ 75.00 RRP
US$ 67.50 REGISTERED USER PRICE
ADD TO CART

Category: Haemolymphatic - Associated with the blood and lymph

Gene: RAS guanyl releasing protein 1 (RASGRP1) on Chromosome 30

Variant Detected: Eskimo Spitz: Nucleotide Insertion, c.452insA, p.Ser266Stop Basset Hound: Nucleotide Deletion, c.509-511delTCT, p.del170Phe

Severity: Scale 4 has a high degree of severity. It generally causes a decreased quality of life and may also decrease the life expectancy.

Mode of Inheritance: Autosomal Recessive

Test Overview: Also known as Thrombopathia a bleeding disorder where platelets are unable to adhere properly to one another leading to clot. Common symptoms include nose bleeds and excessive bleeding around the gums. dogs may also bruise easily (hematomas).

Research Citation(s): Boudreaux MK, et al. Calcium-diacylglycerol guanine nucleotide exchange factor I gene mutations associated with loss of function in canine platelets. (2006) Trans Res, 150(2);81-92.

Associated Breed(s): Mixed Breed,  Bassett Hound ,  American Eskimo Dog,