Spongy Degeneration SDCA2

$75.00 (RRP)



This is an inherited disorder neuro-degenerative disorders characterized by progressive degeneration of cerebellum and extracerebellar structures, these brain structure help coordinate movement. 

Affected puppies start to show symptoms around 4 weeks of age. Symptoms include generalized abnormal gait, seizures, and pacing as well as circling and central blindness. These clinical signs showed very rapid progression. Affected puppies may die during a seizure. 


Nervous system / Neurologic - Associated with the brain, spinal cord and nerves


ATP1B2 gene

Variant Detected:



Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Mauri, N., Kleiter, M., Dietschi, E., Leschnik, M., Högler, S., Wiedmer, M., … Leeb, T. (2017). A SINE Insertion in ATP1B2 in Belgian Shepherd Dogs Affected by Spongy Degeneration with Cerebellar Ataxia (SDCA2). G3: Genes|Genomes|Genetics, 7(8), 2729–2737.

Associated Breed(s):

Belgian Groenendael Shepherd, Belgian Lakenois Shepherd, Belgian Malinois Shepherd, Belgian Tervueren Shepherd , Mixed Breed,