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Also referred to as Glanzmanns Thombasthenia Type 1. Affected dogs have abnormal platelet activity. Platelets are blood cells that are necessary for the normal clotting of blood.
Haemolymphatic - Associated with the blood and lymph
Integrin subunit alpha 2b (ITGA2B) on Chromosome 9
Base Substitution c.1193G>C p.Asp398His
Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.
Mode of Inheritance:
Boudreaux, MK. et al. Molecular and genetic basis for thrombasthenic thrombopathia in otterhounds. (2001) Am J Vet Res 62(11);1798-1804.
Associated Breed(s):Mixed Breed, Otterhound,