Thrombasthenic Thrombopathia (Otterhound Type) Overview
Thrombasthenic Thrombopathia (Otterhound Type)
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Category: Haemolymphatic - Associated with the blood and lymph
Gene: Integrin subunit alpha 2b (ITGA2B) on Chromosome 9
Variant Detected: Base Substitution c.1193G>C p.Asp398His
Severity: Scale 3 has a moderate degree of severity, as it is not a fatal disease, though it can decrease the quality of life.
Mode of Inheritance: Autosomal Recessive
Test Overview: Also referred to as Glanzmanns Thombasthenia Type 1. Affected dogs have abnormal platelet activity. Platelets are blood cells that are necessary for the normal clotting of blood.
Research Citation(s): Boudreaux, MK. et al. Molecular and genetic basis for thrombasthenic thrombopathia in otterhounds. (2001) Am J Vet Res 62(11);1798-1804.
Associated Breed(s): Otterhound, Mixed Breed,