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Thrombasthenic Thrombopathia (Otterhound Type)

US$ 94.00 RRP

US$ 50.00 (USER PRICE)

Test Overview:

Also referred to as Glanzmanns Thombasthenia Type 1. Affected dogs have abnormal platelet activity. Platelets are blood cells that are necessary for the normal clotting of blood.

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

Integrin subunit alpha 2b (ITGA2B) on Chromosome 9

Variant Detected:

Base Substitution c.1193G>C p.Asp398His

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Boudreaux, MK. et al. Molecular and genetic basis for thrombasthenic thrombopathia in otterhounds. (2001) Am J Vet Res 62(11);1798-1804.

Associated Breed(s):

Mixed Breed, Otterhound,