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Thrombasthenic Thrombopathia (Otterhound Type) Overview

Thrombasthenic Thrombopathia (Otterhound Type)
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Category: Haemolymphatic - Associated with the blood and lymph

Gene: Integrin subunit alpha 2b (ITGA2B) on Chromosome 9

Variant Detected: Base Substitution c.1193G>C p.Asp398His

Severity: Scale 3 has a moderate degree of severity, as it is not a fatal disease, though it can decrease the quality of life.

Mode of Inheritance: Autosomal Recessive

Test Overview: Also referred to as Glanzmanns Thombasthenia Type 1. Affected dogs have abnormal platelet activity. Platelets are blood cells that are necessary for the normal clotting of blood.

Research Citation(s): Boudreaux, MK. et al. Molecular and genetic basis for thrombasthenic thrombopathia in otterhounds. (2001) Am J Vet Res 62(11);1798-1804.

Associated Breed(s): Otterhound,  Mixed Breed,