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A Locus (Fawn/Sable;Tri/Tan Points) Overview

A Locus (Fawn/Sable;Tri/Tan Points)
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Description: The A- Series (agouti-signalling peptide) ASIP affects the distribution of eumelanin.  The ASIP gene has four alleles the ay (fawn/red or sable), the aw (wild sable/wild type or wild boar), at (black & tan/tricolour) and the a (solid black).  These four alleles work in a hierarchy - one is dominant over the other.  The Agouti test runs and reports all 4 alleles.

Please Note:  We strongly recommend that you also request a K-Locus test with any A-Locus request as the expression of any A locus results (colour) is stringly influenced by the K-Locus..


Category: Trait (Associated with Phenotype)

Gene: ASIP

Variant Detected: Base Substitution 246 G>T(A82S); G>A (R83H): C>T (p.R96C)

Severity: Scale 1 has a very low degree of severity. It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance: Autosomal Recessive

Test Overview: the agouti-signalling peptide (ASIP) gene have identified four different alleles that affect the pigmentation of coat colour in dogs. In dogs that do not carry the dominant black gene (ky/ky at the K Locus) and are not "e/e" for the E Locus, the agouti gene is allowed to express and determines the colour of the dog's coat. The four alleles work as a hierarchy, with the most dominant allele that the dog has always being expressed (assuming n/n for the K Locus). The most dominant allele is "ay", followed by "aw", then "at", then "a."

Research Citation(s):
Science. 2007 Nov 30; 318(5855): 1418–1423.[PMC2906624]
J Hered. 2003 Jan-Feb;94(1):75-9. [Pubmed/12692166]
br> "Conditions Associated with Coat Color in Dogs." University of Saskatchewan. University of Saskatchewan, 02 June 2011. Web. 03 Apr. 2014. .
Dog Coat Colour Genetics http://doggenetics.co.uk/


Associated Breed(s): Afghan Hound ,  Airedale Terrier,  Alaskan Malamute,  American Bulldog ,  American Cocker Spaniel,  Australian Bulldog,  Australian Cattle Dog,  Australian Kelpie,  Australian Silky Terrier,  Basenji,  Bassett Hound ,  Beagle,  Bedlington Terrier,  Belgian Malinois Shepherd,  Belgian Tervueren Shepherd ,  Bernese Mountain Dog,  Black Russian Terrier ,  Border Collie,  Border Terrier,  Boston Terrier,  Briard,  British Bulldog,  Brittany Spaniel ,  Griffon Bruxellois - Standard,  Bull Terrier,  Bullmastiff,  Cairn Terrier,  Cane Corso Italiano,  Cardigan Welsh Corgi,  Cavalier King Charles Spaniel,  Chesapeake Bay Retriever ,  Chihuahua,  Chow Chow,  Clumber Spaniel ,  Cockapoo,  Coton De Tulear,  Curly Coated Retriever,  Dachshund ,  Miniature Dachshund Long Hair,  Miniature Dachshund Smooth Hair,  Dalmatian,  Dobermann,  Dogue de Bordeaux,  English Setter ,  English Springer Spaniel,  Finnish Lapphund,  Flat Coated Retriever,  Smooth Fox Terrier,  French Bulldog,  Giant Schnauzer,  Golden Retriever,  Goldendoodle,  Gordon Setter ,  Greyhound ,  Havanese,  Irish Setter,  Jack Russell Terrier,  Japanese Chin,  Keeshond,  Kerry Blue Terrier,  Koolie ,  Labradoodle ,  Labrador Retriever,  Lancashire Heeler,  Landseer Newfoundland,  Lapponian Herder,  Lhasa Apso,  Manchester Terrier ,  Mastiff ,  Miki,  Miniature Schnauzer,  Newfoundland,  Norfolk Terrier ,  Norwegian Elkhound,  Norwich Terrier,  Nova Scotia Duck Tolling Retriever ,  Old English Sheepdog ,  Papillon,  Parson Russell Terrier,  Pekingese,  Pembroke Welsh Corgi,  Plott Hound,  Pomeranian,  Toy Poodle,  Miniature Poodle,  Standard Poodle,  Portuguese Water Dog,  Great Pyrenees,  Rat Terrier,  Rhodesian Ridgeback ,  Rottweiler ,  Saluki,  Samoyed,  Schipperke,  Scottish Terrier ,  Sealyham Terrier ,  Shar Pei,  Siberian Husky,  Staffordshire Bull Terrier ,  Swedish Lapphund,  Tenterfield Terrier ,  Tibetan Mastiff,  Tibetan Spaniel,  Tibetan Terrier ,  Volpino Italiano,  Weimaraner,  Cardigan Welsh Corgi,  West Highland White Terrier ,  Whippet ,  Yorkshire Terrier,  Affenpinscher,  Akita ,  American Eskimo Dog,  American Foxhound,  American Staffordshire Terrier,  Anatolian Shepherd,  Australian Cobberdog,  Australian Shepherd,  Australian Stumpy Tail Cattle Dog,  Australian Terrier,  Bearded Collie ,  Belgian Groenendael Shepherd,  Belgian Lakenois Shepherd,  Bichon Frise,  Bloodhound,  Boerboel,  Borzoi,  Bouvier Des Flandres,  Boxer ,  Boykin Spaniel,  Bull Arab,  Canaan Dog,  Catahoula,  Catahoula Leopard Dog,  Cavoodle,  Chinese Crested,  Cocker Spaniel,  Collie Rough,  Collie Smooth,  Coonhound,  Dandie Dinmont Terrier,  Dingo,  English Toy Spaniel ,  English Toy Terrier,  Field Spaniel,  Fox Terrier (Toy),  Wire Fox Terrier,  Foxhound ,  German Shepherd Dog,  German Shorthaired Pointer,  German Spitz ,  Great Dane,  Groodle,  Harlequin Pinscher,  Havanese Terrier Toy,  Hungarian Kuvasz,  Hungarian Vizsla,  Ibizan Hound,  Irish Terrier,  Irish Wolfhound,  Italian Greyhound,  Italian Spinone,  Jagd Terrier,  Japanese Shiba Inu,  Japanese Spitz,  Komondor,  Lagotto Romagnolo,  Lakeland Terrier ,  Leonberger,  Lowchen,  Maltese,  Maremma Sheepdog,  Mexican Hairless ,  Miniature Australian Shepherd,  Miniature Bull Terrier,  Miniature Dachshund Wire Hair,  Miniature Fox Terrier,  Miniature Pinscher ,  Miniature Yorkshire Terrier,  Mixed Breed,  Mountain Dog ,  Munsterlander,  Murray River Retriever,  Neapolitan Mastiff,  Old English Mastiff ,  Peruvian Hairless Dog,  Pug,  Puli,  Saint Bernard ,  Schnoodle,  Scottish Deerhound,  Sealydale Terrier,  Shetland Sheepdog,  Shiba Inu,  Shih tzu,  Silky Terrier ,  Skye Terrier,  Sloughi,  Smithfield,  Soft Coated Wheaten Terrier,  Spoodle,  Standard Dachshund Long Hair,  Standard Dachshund Smooth Hair,  Standard Dachshund Wire Hair,  Standard Schnauzer,  Sussex Spaniel,  Water Spaniel ,  Welsh Springer Spaniel,  White Swiss Shepherd,  Australian Labradoodle ,  Kaninchen Dachshund,  Shortybull,