D (Dilute) Locus Overview
D (Dilute) Locus
US$ 75.00 RRP
US$ 67.50 REGISTERED USER PRICEADD TO CART
Description: The protein melanophilin (MLPH gene) is responsible for the dilute coat colour. This variation causes black, brown and yellow hair (eumelanin or phaeomelanin pigments) to be diluted. Referred to as blue, charcoal, grey and in cobination with other colours lilac or champagne. A normal result is usually reported as DD (no copies of dilute), with carrier as Dd (one copy of the dilute) and a dilute colour dog affected is reported dd.
Category: Trait (Associated with Phenotype)
Variant Detected: Base Substitution
Severity: Scale 1 has a very low degree of severity. It is a trait and so is tested based on preference, not usually for health concerns.
Mode of Inheritance: Autosomal Recessive
Test Overview: The protein melanophilin (MLPH gene) is responsible for the dilute coat colour. This variation causes black, brown and yellow hair (eumelanin or phaeomelanin pigments) to be diluted. Referred to as blue, charcoal, grey and in combination with other colours - lilac or champagne. A normal result is usually reported as DD (no copies of dilute), with carrier as Dd (one copy of the dilute) and a dilute colour dog affected is reported dd.
University of Bern, 02 May 2007. Web. 02 Apr. 2014.
Sir James Dunn Animal Welfare Centre and the Canadian Veterinary Medical Association, 02 Feb. 2004. Web. 03 Apr. 2014.
. J Hered. 2007; 98(5):468-73. [PubMed: 17519392]
. Vet Rec. 1995 Oct 14;137(16):412. [PubMed: 8545945]
Vet Rec. 1988 Apr 9;122(15):360-1.
Aust Vet J. 1993 Oct;70(10):388-9. [PubMed: 8257319] Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs.
BMC Genet. 2005 Jun 16; 6:34. [PubMed: 15960853]
Associated Breed(s): Affenpinscher, Afghan Hound , Airedale Terrier, Akita , Alaskan Malamute, American Bulldog , American Cocker Spaniel, American Eskimo Dog, American Foxhound, American Staffordshire Terrier, Anatolian Shepherd, Australian Cobberdog, Australian Kelpie, Australian Shepherd, Australian Silky Terrier, Australian Stumpy Tail Cattle Dog, Australian Terrier, Basenji, Bassett Hound , Bearded Collie , Belgian Groenendael Shepherd, Belgian Lakenois Shepherd, Belgian Malinois Shepherd, Belgian Tervueren Shepherd , Bernese Mountain Dog, Bichon Frise, Black Russian Terrier , Bloodhound, Boerboel, Borzoi, Bouvier Des Flandres, Boxer , Boykin Spaniel, Brittany Spaniel , Bull Arab, Bullmastiff, Bull Terrier, Cairn Terrier, Canaan Dog, Cardigan Welsh Corgi, Catahoula, Catahoula Leopard Dog, Cavoodle, Chesapeake Bay Retriever , Chinese Crested, Chow Chow, Clumber Spaniel , Cockapoo, Cocker Spaniel, Collie Rough, Collie Smooth, Coonhound, Coton De Tulear, Curly Coated Retriever, Dandie Dinmont Terrier, Dingo, Dogue de Bordeaux, English Setter , English Springer Spaniel, English Toy Spaniel , English Toy Terrier, Field Spaniel, Finnish Lapphund, Smooth Fox Terrier, Fox Terrier (Toy), Wire Fox Terrier, Foxhound , German Shorthaired Pointer, German Spitz , Giant Schnauzer, Golden Retriever, Goldendoodle, Gordon Setter , Great Dane, Great Pyrenees, Greyhound , Griffon Bruxellois - Standard, Groodle, Harlequin Pinscher, Havanese, Havanese Terrier Toy, Hungarian Kuvasz, Hungarian Vizsla, Ibizan Hound, Irish Setter, Irish Terrier, Irish Wolfhound, Italian Spinone, Jack Russell Terrier, Jagd Terrier, Japanese Chin, Japanese Shiba Inu, Japanese Spitz, Keeshond, Kerry Blue Terrier, Komondor, Lagotto Romagnolo, Lakeland Terrier , Lancashire Heeler, Landseer Newfoundland, Lapponian Herder, Leonberger, Lhasa Apso, Lowchen, Maltese, Manchester Terrier , Maremma Sheepdog, Mastiff , Xoloitzcuintle (Mexican Hairless), Miki, Miniature Australian Shepherd, Miniature Bull Terrier, Miniature Dachshund Wire Hair, Miniature Fox Terrier, Miniature Pinscher , Miniature Schnauzer, Miniature Yorkshire Terrier, Mixed Breed, Mountain Dog , Munsterlander, Murray River Retriever, Neapolitan Mastiff, Norfolk Terrier , Norwegian Elkhound, Norwich Terrier, Old English Mastiff , Old English Sheepdog , Parson Russell Terrier, Pekingese, Peruvian Hairless Dog, Plott Hound, Pomeranian, Pug, Puli, Rat Terrier, Rottweiler , Saint Bernard , Saluki, Samoyed, Schipperke, Schnoodle, Scottish Deerhound, Sealydale Terrier, Sealyham Terrier , Shar Pei, Shetland Sheepdog, Shiba Inu, Shih tzu, Siberian Husky, Silky Terrier , Skye Terrier, Sloughi, Smithfield, Soft Coated Wheaten Terrier, Spoodle, Standard Dachshund Long Hair, Standard Dachshund Smooth Hair, Standard Dachshund Wire Hair, Standard Schnauzer, Sussex Spaniel, Swedish Lapphund, Tenterfield Terrier , Volpino Italiano, Water Spaniel , Welsh Springer Spaniel, West Highland White Terrier , Whippet , Yorkshire Terrier, Labrador Retriever, French Bulldog, Border Collie, Rhodesian Ridgeback , Dobermann, Kaninchen Dachshund, British Bulldog, Scottish Terrier , Alaskan Husky, American Bully , American Hairless, Asian Shepherd, Australasian Bosdog, Australian Bulldog, Australian Cattle Dog, Australian Labradoodle , Beagle, Bedlington Terrier, Border Terrier, Boston Terrier, Bracco Italiano, Brazilian Terrier, Briard, Cane Corso Italiano, Cavador, Cavalier King Charles Spaniel, Chihuahua, Dachshund , Dalmatian, Dutch Shepherd, Dwarf Poodle, English Pointer, English Shepherd, Flat Coated Retriever, German Pinscher, German Shepherd Dog, German Wirehaired Pointer, Glen of Imaal Terrier, Grand Basset Griffon Vendeen, Greater Swiss Mountain Dog, Hungarian Wirehaired Vizsla, Huntaway, Irish Water Spaniel, Italian Greyhound, Koolie , Kromfohrländer, Labradoodle , Labradoodle Retrodoodle , Large Munsterlander, Miniature Dachshund Long Hair, Miniature Dachshund Smooth Hair, Miniature Poodle, Moodle, Native American Indian Dog, New Zealand Heading Dog, Newfoundland, Nova Scotia Duck Tolling Retriever , Old Danish Pointing Dog, Otterhound, Papillon, Pembroke Welsh Corgi, Petit Basset Griffon Vendeen, Phalene, Pharaoh Hound, Pointer, Polish Lowland Sheepdog, Portuguese Podengo, Portuguese Water Dog, Prague Ratter, Presa de Canario, Pumi, Red and White Setter, Russian Toy, Sarplaninac, Schapendoes, Short Bully, Shortybull, Spanish Water Dog, Staffordshire Bull Terrier , Standard Poodle, Swedish Vallhund, Tibetan Mastiff, Tibetan Spaniel, Tibetan Terrier , Toy Poodle, Weimaraner, Weimaraner Long Hair , Welsh Terrier , White Swiss Shepherd,