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E Locus e2 Overview

E Locus e2
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Category: Trait (Associated with Phenotype)

Gene: MC1R

Severity: It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance: Autosomal Recessive

Test Overview: The pale cream colour produced by the e2 variant occurs in Australian Cattle Dog and appears limited to this breed and its crossbreds

Research Citation(s): Durig N, A Letko, SH Rasouliha, R Loechel, A Kehl, MK Hytonen, H Lohi, N Mauri, J Dietrich, M Wiedmer, M Drogemuller, V Jagannathan, SM Schmutz, T Leeb. 2018. Two MC1R loss-of-function alleles in cream-coloured Australian Cattle Dogs and white Huskies. Animal Genetics 49:284-290.

Associated Breed(s): Mixed Breed,  Australian Cattle Dog,  Australian Shepherd,  Australian Stumpy Tail Cattle Dog,  Collie Rough,  Collie Smooth,  Border Collie,  Koolie ,