Harlequin (H) Pattern (Great Dane Type) Overview
Harlequin (H) Pattern (Great Dane Type)
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Category: Trait (Associated with Phenotype)
Variant Detected: Base Substitution T>C
Severity: Scale 3 has a moderate degree of severity, as it is not a fatal disease, though it can decrease the quality of life.
Mode of Inheritance: Autosomal Dominant
Test Overview: The Harlequin gene causes a white background and the spots increase in size. Dogs that are not merle, cannot express the Harlequin colour/pattern. Breeding two dogs that both have a copy of the h locus “NH” is not recommended. A dog with two copies of Harlequin has not been observed and It is presumed to be lethal in utero. This gene is inherited as a dominant trait.
Gene. 2008 Jul 15; 418(1-2):49-52. [PubMed: 18513894]
. Genomics. 2011 Apr; 97(4):244-8. [PubMed: 21256207]
Associated Breed(s): Great Dane, Harlequin Pinscher, Mixed Breed,