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The Harlequin gene causes a white background and the spots increase in size. Dogs that are not merle, cannot express the Harlequin colour/pattern. Breeding two dogs that both have a copy of the h locus “NH” is not recommended. A dog with two copies of Harlequin has not been observed and It is presumed to be lethal in utero. This gene is inherited as a dominant trait.
Trait (Associated with Phenotype)
Base Substitution T>C
Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.
Mode of Inheritance:
Gene. 2008 Jul 15; 418(1-2):49-52. [PubMed: 18513894]
. Genomics. 2011 Apr; 97(4):244-8. [PubMed: 21256207]
Associated Breed(s):Great Dane, Harlequin Pinscher, Mixed Breed,