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Merle - SINGLE ASSAY TEST Overview

Merle - SINGLE ASSAY TEST
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Category: Trait (Associated with Phenotype)

Gene: SILV

Variant Detected: 10. On 3? end of SINE insertion, oligo(dA)-rich tails

Severity: Scale 4 has a high degree of severity. It generally causes a decreased quality of life and may also decrease the life expectancy.

Mode of Inheritance: Autosomal Dominant

Test Overview: Merle dog coat color is a coat pattern in domestic dogs, specific for patches of diluted pigment mixed together with normal melanin. Dog homozygous for merle gene is known as double merle (genotype MM). Double merle has been recognized as sublethal and is associated with many abnormalities in the reproductive, cardiac and skeletal system. Many of these abnormalities share similarities with Waardenburg syndrome (WS), an autosomal dominant auditory-pigmentation disorder in humans.

Research Citation(s): Leigh Anne Clark, Jacquelyn M. Wahl, Christine A. Rees, and Keith E. Murphy (2006): Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog. PNAS 103 (5) 1376-1381, 2006,doi:10.1073/pnas.0506940103 Hedan, B. et al. (2006.): Coat color in dogs: identification of the Merle locus in the Australian shepherd breed. BCM Vet Res. 2:9. Strain et al. (2009.): Prevalence of Deafness in Dogs Heterozygous or Homozygous for the Merle Allele. J Vet Intern Med 2009; 23:282-286.

Associated Breed(s): Border Collie,  Australian Shepherd,  Dachshund ,  Cardigan Welsh Corgi,  French Bulldog,  American Cocker Spaniel,  Chihuahua,  Collie Rough,  Collie Smooth,  American Staffordshire Terrier,  Koolie ,  Miniature Australian Shepherd,  Miniature Dachshund,  Miniature Dachshund Long Hair,  Miniature Dachshund Smooth Hair,  Miniature Dachshund Short Hair,