Merle - SINGLE ASSAY TEST Overview
Merle - SINGLE ASSAY TEST
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This test is offered under the terms of a sublicense granted by IDEXX Laboratories Inc.
Category: Trait (Associated with Phenotype)
Variant Detected: 250 base pair SINE insertion, oligo(dA)-rich tails with length polymorphism. Detects and reports all the 7 alleles on the M Locus (Mh, M, Ma+, Ma, Mc+, Mc and m)
Severity: Scale 2 has a low degree of severity. It has mild effects and generally does not pose any significant health concerns, or is easily managed.
Mode of Inheritance: Autosomal Dominant with Incomplete Penetrance
Test Overview: Please Note - The Merle test is offered under the terms of a sublicense granted by IDEXX Laboratories Inc. Merle dog coat color is a coat pattern in domestic dogs, specific for patches of diluted pigment mixed together with normal melanin. Dog homozygous for merle gene is known as double merle (genotype MM). Double merle has been recognized as sublethal and is associated with many abnormalities in the reproductive, cardiac and skeletal system. Many of these abnormalities share similarities with Waardenburg syndrome (WS), an autosomal dominant auditory-pigmentation disorder in humans.
Research Citation(s): Langevin et al; PLoS One. 2018; 13(9): Merle phenotypes in dogs – SILV SINE insertions from Mc to Mh.
Leigh Anne Clark, Jacquelyn M. Wahl, Christine A. Rees, and Keith E. Murphy (2006): Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog. PNAS 103 (5) 1376-1381, 2006,doi:10.1073/pnas.0506940103
Hedan, B. et al. (2006.): Coat color in dogs: identification of the Merle locus in the Australian shepherd breed. BCM Vet Res. 2:9.
Strain et al. (2009.): Prevalence of Deafness in Dogs Heterozygous or Homozygous for the Merle Allele. J Vet Intern Med 2009; 23:282-286.
Langevin M, SynkovaH, Jancuskova T, Pekova S (2018) Merle phenotypes in dogs – SILV SINE insertions from Mc to Mh. PLoS ONE 13(9): e0198536.https://doi.org/10.1371/journal. pone.0198536
Associated Breed(s): Border Collie, Australian Shepherd, Dachshund , Cardigan Welsh Corgi, French Bulldog, American Cocker Spaniel, Chihuahua, Collie Rough, Collie Smooth, American Staffordshire Terrier, Koolie , Miniature Australian Shepherd, Miniature Dachshund, Miniature Dachshund Long Hair, Miniature Dachshund Smooth Hair, Miniature Dachshund Short Hair, Australian Bulldog, British Bulldog, Aussiedoodle, Sheepadoodle,