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Screw Tail (DVL2) - SINGLE ASSAY TEST

US$ 75.00 RRP

US$ 67.50 (USER PRICE)

Test Overview:

A gene known as DISHEVELLED 2 or DVL2, in all of the bulldogs and Frenchies and in nearly every terrier (94 per cent). But the mutation couldn’t be spotted in any other dog, short-faced or not. The mutation, they also found, seems to alter a protein that helps cells communicate with one another during a dog’s development in the womb. That subtle change might then account for the misshapen spines seen in these poor dogs. The DVL2 mutation they spotted in these dogs is very much like the mutations in the human DVL1 and DVL3 genes that cause Robinow syndrome in people

Category:

Trait (Associated with Phenotype)

Gene:

DVL2

Variant Detected:

frameshift mutation in the WNT pathway gene DISHEVELLED 2 (DVL2) (Chr5: 32195043_32195044del, p = 4.37 X 10?37)

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Dominant with Incomplete Penetrance

Research Citation(s):

https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007850

Associated Breed(s):

American Bulldog , American Bully , American Pit Bull Terrier, American Staffordshire Terrier, Australian Bulldog, Boston Terrier, British Bulldog, Bull Arab, Bull Terrier, Bullmastiff, French Bulldog,