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Inherited myopathy in the Great Dane is an autosomal recessive trait characterized by generalized muscle atrophy, exercise intolerance, exercise-induced tremor and muscle wasting.
Symptoms of the disease typically appear before 10 months of age and rapidly progress within the next 6-8 months of life before most animals succumb to severe debilitating muscle weakness.
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Associated Breed(s):
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Category:
Genetic Diseases
Severity:
Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.
Gene:
Bridging integrator 1 (BIN1) on chromosome 19
Variant Detected:
IVS10-2 A>G at the exon 11 acceptor splice site of BIN1
Mode of Inheritance:
Recomended Screening:
Research Citation(s):