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Gangliosidosis is a type of lysosomal storage disease, caused by an inherited error in how lipid (fat) is metabolised within cells. Cats with GM1 gangliosidosis lack the beta-galactosidase enzyme that is needed to metabolise, or break down certain lipids, and this causes certain lipid molecules to build up inside cells because they cannot be excreted. Eventually this interferes with normal processes in the cell, and the cell cannot perform its normal functions anymore. Two types of gangliosidosis are seen in cats, called GM1 gangliosidosis, which is seen in the Korat, Siamese (and Siamese related breeds) and domestic cat, and GM2 gangliosidosis, seen in the Korat, Burmese and domestic cat. GM1 Gangliosidosis causes gangliosides ( lipid-carbohydrate molecules derived from cell membranes) to build up in the cells of the central nervous system (the brain) and leads to neurologic signs in affected cats. This disease is inherited as autosomal recessive trait, meaning for a cat to be affected she must inherit a defective gene from each of her parents. Cats with only one copy of the affected gene are not affected, but are carriers of the disease and can pass the trait on to future generations. Cats with GM1 gangliosidosis are affected at a young age, usually between 3-4 months of age, and will generally be severely affected and require euthanasia by around 12 months of age. The signs are progressive, from weakness in the legs, a fine head tremor and weight loss, to a wobbly gait and other gait abnormalities such as frequent falling, and finally to depression, difficulty eating and drinking, a more severe tremor and even seizures. Affected kittens may have stunted growth, and may have facial abnormalities (such as a small skull with a flat, broad face). There may also be clouding of the eyes and vision problems. There is no cure for GM1 gangliosidosis, but genetic testing is available so that carrier animals may be detected. The only way to manage the disease is prevention by avoiding breeding carrier animals. Genetic diversity can be maintained by breeding carrier animals that have otherwise valuable traits to known "clear" animals, and only breeding with their tested "clear" kittens.
Nervous system / Neurologic - Associated with the brain, spinal cord and nerves
Base Substitution G>C
Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.
Mode of Inheritance:
1. Genetic testing of all breeding animals prior to entering a breeding program (e.g. at 16 weeks). 2. Ensure breeding of clear to clear animals, or carrier to clear animals only.
Mol Genet Metab. 2008 Jun;94(2):212-21
Associated Breed(s):Burmese, Domestic Short Hair, Korat, Siamese, Tonkinese,